Table 1. Thermodynamic Parameters and Dissociation Constants of hHint1–Ligand Complexes Determined Using ITC.

compd	Kd (μM)	ΔH (kcal mol–1)	–TΔS (kcal mol–1)	ΔG (kcal mol–1)
3a	3.65 ± 1.00	–13.54 ± 1.00	9.54 ± 4.17	–4.1 ± 2.0
4	0.81 ± 0.11	–16.51 ± 0.17	8.05 ± 0.88	–8.46 ± 0.4
5	2.90 ± 0.25	–13.59 ± 1.12	7.71 ± 0.27	–5.81 ± 1.0
6	0.92 ± 0.07	–14.75 ± 0.12	6.57 ± 0.17	–8.24 ± 0.12
7	0.23 ± 0.01	–17.31 ± 0.05	8.19 ± 0.13	–9.13 ± 0.11
GMPb	67 ± 7.9

^aData adapted from previously published result by Garzon et al.²

^bData shown from the NMR titrations previously reported by Shapiro and co-workers.²²