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. 2016 Jul 5;7(8):813–818. doi: 10.1021/acsmedchemlett.6b00224

Figure 4.

Figure 4

KU-32 analogs worsen mitochondrial bioenergetics in the 50B11 neuronal cell line. (A and B) 50B11 cells were treated for 24 h with KU-32 or its analogs (5 μM each) for mitochondrial bioenergetic analysis. The basal oxygen consumption rate (OCR) was measured prior to the addition of (a) oligomycin, to assess ATP-coupled respiration; (b) FCCP, to measure uncoupled respiration; and (c) rotenone + antimycin A, to assess nonmitochondrial respiration. (C) OCR values at 88.3 min were plotted and compared to the DMSO value.