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Cytotoxic KU-32 analogs down-regulate the expression of Hsp90 client proteins. PC3-MM2 cells were treated with the cytotoxic analogs of KU-32 (5D, 5E, 5H, and 5I) with the concentrations of (H) 3 × IC50 and (L) 0.5 × IC50 for 24 h, and the levels of known Hsp90 client proteins were measured. Actin was used as the loading control.
