Scheme 1. Synthesis of KU-32 Analogs.
Reagents and conditions: (a) BF3·Et2O, DCM, rt, 2 h, 70%; (b) 10% Pd/C, H2, EtOAc, rt, 4 h, ∼100%; (c) R-COOH, EDCl·HCl, DMAP, pyridine, DCM, rt, 12 h, 50–70%; (d) 2% Et3N/MeOH, rt, 12 h, 40–70%.
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