Scheme 2. Synthesis of Piperazines 7–11 and 14–16.
Reagents and conditions: (a) T3P, Et3N, CH2Cl2, rt, overnight, 62–96%; (b) Lindlar’s catalyst, quinoline, H2, EtOAc, quant.; (c) CrCl2, CH2ICl, THF, reflux, overnight, 57%.
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