Fig. (1).

Summary of expression and role of mGlu receptors in synaptic plasticity at SC-CA1 synapses. Afferents projecting from CA3 pyramidal cells synapse onto the dendrites of CA1 pyramidal neurons. mGlu₇ is expressed presynaptically and its activation may be involved in regulating LTP. Both mGlu₁ and mGlu₅ are expressed postsynaptically on CA1 pyramidal neurons, where they are known to regulate both LTP and LTD. mGlu₃ is expressed on astrocytes within area CA1 and is involved in the induction of a short term depression also reliant on activation of β adrenergic receptors. Abbreviations: LTP- long term potentiation, LTD- long term depression, β AR- β adrenergic receptors, STP- short term plasticity.