Fig. (8).

A) The best-ranked docking solution of photoexcited alloswitch-1 (in violet) in mGlu5 (in beige) “in violet light”. B) After 100 ns of MD simulation “in violet light”. C) Pronounced lateral oscillation and rocking of photoexcited alloswitch-1 in the first 10 ns of MD simulation (two individual conformations displayed within a combined volume). H-bonds are shown as orange lines. For visualisation purposes, the backbone of TM6 is not shown, however the sidechains of residues W785 and T781 on TM6 are included (in the foreground). Regarding helix position, TM5 is foreground left, TM7 is foreground right. In the background, TM3 is centre-left and TM2 is centre-right.