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Hypothesized model. Colonic intraluminal pH is decreased and SCFAs production is increased suggesting higher fermentation in patients with IBS compared with HC. SCFAs are effectively absorbed (> 95% of SCFAs) in the GI tract and only a small portion (~5% of total SCFAs) is excretion in feces. Both processes can affect and are affected by intestinal transit. Abbreviations: SCFAs, short chain fatty acids; IBS, irritable bowel syndrome; HC, healthy control.
