FIG 4.

(a) Upregulated (red) and downregulated (blue) expression profiles of C. cellulovorans genes related to thiamine metabolism at the early, mid-, and late exponential growth phases in response to cocultivation with R. palustris. DEGs (genes differentially expressed at any time point) are marked with an asterisk (*). (b) The genes indicated in panel a are shown in the corresponding metabolic pathways. HET, 5-(2-hydroxyethyl)-4-methylthiazole; HET-P, HET phosphate; HMP, 4-amino-5-hydroxymethyl-2-methylpyrimidine; HMP-P, HMP phosphate; HMP-PP, HMP diphosphate; TMP, thiamine monophosphate; TDP, thiamine diphosphate; AIR, 1-(5′-phospho-ribosyl)-5-amino-imidazole; COSH, thiocarboxylate. A question mark (?) indicates that the gene has not been annotated in the R. palustris genome.