Skip to main content
. 2016 Mar 1;5(3):254–260. doi: 10.1002/open.201500203

Table 1.

Enzyme screening for the acylation of (±)‐7 [a].

Entry Enzyme ee s [b] [%] ee p [b] [%] Conv. [%] E
1 CAL‐B 4 99 4 >200
2 PS‐IM 1.5 99 1.5 >200
3 AK No reaction
4 CAL‐A 3 24 11 1.6

[a] Substrate (0.0125 mmol, 3.7 mg); CAL‐B (230 mg), PS‐IM (248 mg), AK (338 mg), CAL‐A (231 mg, 70 mm cartridge); toluene (1 mL); 1.1 equiv vinyl acetate (1.2 μL); 45 °C; 0.1 mL min−1 flow rate; 1 bar; 1 cycle. [b] According to HPLC.