Table 2.

Acyl donor screening for the acylation of (±)‐7 ^[a].

Entry	Acyl donor	ee s [b] [%]	ee p [b] [%]	Conv. [%]	E
1	ethyl acetate	No reaction
2	isopropenyl acetate	No reaction
3	vinyl acetate	4	99	4	>200
4	butyric anhydride	31	63	32	6
5	acetic anhydride	20	99	17	>200
6	2,2,2‐trifluoroethyl butyrate	12	42	22	2.7

[a] Substrate (0.0125 mmol, 3.7 mg); CAL‐B (230 mg, 70 mm cartridge); toluene (1 mL); 1.1 equiv acyl donor; 60 °C, 0.1 mL min⁻¹ flow rate; 1 bar; 1 cycle. [b] According to HPLC.