Table 4.

Solvent screening for the acylation of (±)‐7 ^[a].

Entry	Solvent	ee s [b] [%]	ee p [b] [%]	Conv. [%]	E
1	toluene	20	99	17	>200
2	methyl tert‐butyl ether	4	99	4	>200
3	acetonitrile	1	95	1	39
4	diisopropyl ether	20	99	17	>200
5	chloroform	2	73	3	7
6	1,4‐dioxane	3	99	3	>200

[a] Substrate (0.0125 mmol, 3.7 mg); CAL‐B (230 mg, 70 mm cartridge); solvent (1 mL); 1.1 equiv acetic anhydride (1.2 μL); 60 °C; 0.1 mL min⁻¹ flow rate; 1 bar; 1 cycle. [b] According to HPLC.