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. Author manuscript; available in PMC: 2016 Aug 15.
Published in final edited form as: J Gerontol Geriatr Res. 2015 Sep 23;4(5):240. doi: 10.4172/2167-7182.1000240

Table 5.

Leptin and adiponectin in association with cognitive test score, by HIV infection status: Brooklyn WIHS.

All HIV+ HIV−
Log Adipokine n b(95% CI) p-value n b(95% CI) p-value n b(95% CI) p-value
Trails A
Leptin
Model 1 353 0.90 (−0.63, 2.42) 0.248 246 0.77 (−1.20, 2.74) 0.444 107 2.26 (0.05, 4.46) 0.045
Model 2 306 3.16 (0.97, 5.35) 0.005 215 2.96 (0.12, 5.81) 0.041 91 4.84 (1.58, 8.11) 0.004
HMW adiponectin
Model 1 348 −1.35 (−3.81, 1.10) 0.279 244 −0.91 (−4.01, 2.18) 0.561 104 −2.91 (−6.59, 0.78) 0.121
Model 2 302 −2.13 (−4.84, 0.58) 0.123 213 −1.98 (−5.32, 1.37) 0.245 89 −1.49 (−6.32, 3.34) 0.541
Total adiponectin
Model 1 354 2.30 (−0.91, 5.51) 0.160 247 2.32 (−1.66, 6.30) 0.251 107 1.68 (−3.53, 6.89) 0.523
Model 2 307 1.05 (−2.44, 4.55) 0.554 216 2.77 (−1.73, 7.26) 0.227 91 −2.71 (−8.61, 3.18) 0.363
HMW adiponectin/total adiponectin ratio
Model 1 348 −1.35 (−3.81, 1.10) 0.279 244 −0.91 (−4.01, 2.18) 0.561 104 −2.91 (−6.59, 0.78) 0.121
Model 2 302 −3.55 (−8.48, 1.39) 0.159 213 −3.77 (−9.71, 2.18) 0.213 89 −2.85 (−12.13, 6.43) 0.542
Trails B
Leptin
Model 1 352 1.64 (−3.26, 6.53) 0.512 245 −0.94 (−7.39, 5.52) 0.776 107 8.29 (1.50, 15.08) 0.017
Model 2 305 7.67 (0.75, 14.58) 0.030 214 4.86 (−4.01, 13.74) 0.281 91 15.48 (4.50, 26.44) 0.006
HMW adiponectin
Model 1 347 0.85 (−7.05, 8.76) 0.832 243 2.49 (−7.62, 12.61) 0.628 104 −4.48 (−16.10, 7.13) 0.446
Model 2 301 −2.11 (−10.58, 6.36) 0.624 212 −2.58 (−12.81, 7.65) 0.619 89 −3.48 (−19.77, 12.80) 0.671
Total adiponectin
Model 1 353 6.94 (−3.37, 17.26) 0.186 246 12.59 (−0.37, 25.55) 0.057 107 −8.69 (−24.80, 7.42) 0.287
Model 2 306 4.51 (−6.40, 15.42) 0.416 215 12.42 (−1.31, 26.16) 0.076 91 −18.22 (−37.64, 1.21) 0.066
HMW adiponectin/total adiponectin ratio
Model 1 347 0.85 (−7.05, 8.76) 0.832 243 2.49 (−7.62, 12.61) 0.628 104 −4.48 (−16.10, 7.13) 0.446
Model 2 301 −3.14 (−18.57, 12.29) 0.689 212 −2.48 (−20.65, 15.69) 0.788 89 −16.21 (−47.31, 14.90) 0.303
Symbol Digit Modalities Test (SDMT)
Leptin
Model 1 348 0.37 (−0.75, 1.49) 0.515 242 0.73 (−0.66, 2.13) 0.303 106 −0.80 (−2.71, 1.10) 0.405
Model 2 302 −1.01 (−2.53, 0.50) 0.190 212 −0.33 (−2.18, 1.52) 0.727 90 −3.22 (−5.96, −0.48) 0.022
HMW adiponectin
Model 1 343 −0.33 (−2.12, 1.46) 0.716 240 −0.26 (−2.43, 1.90) 0.810 103 −0.28 (−3.50, 2.93) 0.862
Model 2 298 0.38 (−1.48, 2.25) 0.686 210 0.52 (−1.63, 2.68) 0.633 88 −1.42 (−5.44, 2.60) 0.485
Total adiponectin
Model 1 349 −0.83 (−3.17, 1.51) 0.486 243 −1.28 (−4.08, 1.52) 0.370 106 0.47 (−3.97, 4.90) 0.835
Model 2 303 0.46 (−1.93, 2.85) 0.706 213 −0.67 (−3.58, 2.23) 0.649 90 3.94 (−0.87, 8.75) 0.107
HMW adiponectin/total adiponectin ratio
Model 1 343 −0.33 (−2.12, 1.46) 0.716 240 −0.26 (−2.43, 1.90) 0.810 103 −0.28 (−3.50, 2.93) 0.862
Model 2 298 0.16 (−3.23, 3.56) 0.925 210 0.35 (−3.50, 4.21) 0.856 88 −0.80 (−8.56, 6.96) 0.837
Stroop – Color
Leptin
Model 1 313 1.64 (−0.23, 3.51) 0.086 215 2.12 (−0.30, 4.55) 0.086 98 1.07 (−1.81, 3.96) 0.463
Model 2 274 1.58 (−1.14, 4.30) 0.254 189 1.51 (−2.00, 5.03) 0.397 85 0.61 (−3.67, 4.89) 0.777
HMW adiponectin
Model 1 308 0.55 (−2.54, 3.64) 0.726 213 −0.14 (−3.93, 3.65) 0.944 95 2.13 (−3.20, 7.46) 0.430
Model 2 270 −0.08 (−3.40, 3.24) 0.963 187 −1.48 (−5.55, 2.60) 0.475 83 2.13 (−3.95, 8.21) 0.487
Total adiponectin
Model 1 314 −2.36 (−6.37, 1.65) 0.248 216 −2.47 (−7.40, 2.45) 0.324 98 −1.75 (−8.78, 5.28) 0.623
Model 2 275 −3.86 (−8.24, 0.50) 0.083 190 −4.04 (−9.58, 1.50) 0.152 85 −2.00 (−9.54, 5.55) 0.600
HMW adiponectin/total adiponectin ratio
Model 1 308 −0.06 (−3.25, 3.14) 0.973 213 −0.14 (−3.93, 3.65) 0.944 95 2.13 (−3.20, 7.46) 0.430
Model 2 270 1.99 (−4.27, 8.25) 0.532 187 −0.59 (−8.14, 6.97) 0.879 83 7.58 (−4.03, 19.19) 0.197
Stroop – Word
Leptin
Model 1 314 1.12 (−0.44, 2.69) 0.158 216 1.91 (−0.05, 3.87) 0.056 98 −0.07 (−2.75, 2.60) 0.956
Model 2 275 0.85 (−1.44, 3.13) 0.467 190 0.96 (−1.86, 3.78) 0.503 85 −0.07 (−4.29, 4.16) 0.975
HMW adiponectin
Model 1 309 0.60 (−1.98, 3.19) 0.647 214 0.70 (−2.37, 3.77) 0.653 95 0.09 (−4.85, 5.03) 0.972
Model 2 271 0.66 (−2.13, 3.46) 0.640 188 0.23 (−3.05, 3.50) 0.891 83 0.79 (−5.23, 6.80) 0.796
Total adiponectin
Model 1 315 −1.41 (−4.76, 1.94) 0.408 217 −0.71 (−4.70, 3.28) 0.726 98 −3.77 (−10.23, 2.69) 0.250
Model 2 276 −2.24 (−5.93, 1.44) 0.231 191 −1.52 (−5.98, 2.95) 0.503 85 −4.12 (−11.52, 3.27) 0.270
HMW adiponectin/total adiponectin ratio
Model 1 309 0.25 (−2.37, 2.87) 0.850 214 0.70 (−2.37, 3.77) 0.653 95 0.09 (−4.85, 5.03) 0.972
Model 2 271 1.12 (−4.15, 6.40) 0.676 188 0.72 (−5.34, 6.78) 0.815 83 0.33 (−11.25, 11.91) 0.955
Stroop – Interference
Leptin
Model 1 308 4.67 (1.54, 7.79) 0.004 2 11 4.90 (0.96, 8.84) 0.015 97 3.93 (−1.46, 9.31) 0.151
Model 2 271 4.12 (−0.27, 8.51) 0.066 187 4.53 (−0.91, 9.98) 0.102 84 3.66 (−4.66, 11.97) 0.384
HMW adiponectin
Model 1 303 −1.02 (−6.28, 4.24) 0.703 209 −1.37 (−7.65, 4.90) 0.667 94 −0.28 (−10.26, 9.69) 0.955
Model 2 267 −0.41 (−5.80, 4.98) 0.882 185 −3.05 (−9.44, 3.35) 0.348 82 7.33 (−4.25, 18.91) 0.211
Total adiponectin
Model 1 309 −0.27 (−7.08, 6.54) 0.938 212 2.63 (−5.46, 10.73) 0.522 97 −7.71 (−20.90, 5.48) 0.249
Model 2 272 0.29 (−6.84, 7.43) 0.936 188 2.26 (−6.44, 10.96) 0.609 84 −6.70 (021.40, 8.01) 0.367
HMW adiponectin/total adiponectin ratio
Model 1 303 −1.85 (−7.21, 3.51) 0.498 209 −1.37 (−7.66, 4.90) 0.667 94 −0.28 (−10.26, 9.69) 0.955
Model 2 267 −1.24 (−11.37, 8.89) 0.810 185 −4.83 (−16.58, 6.91) 0.418 82 10.62 (−12.04, 33.27) 0.353

Model 1 adjusts for age

Model 2 adjusts for age, education, race, BMI, diabetes. Models of HIV+ also included current CD4 count.