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Haematoxylin-eosin staining and 2SC immunohistochemical staining of four uterine leiomyomas from two HLRCC patients (original magnification, × 200). Tumours deficient for FH and without a MED12 mutation (top panel; patient B3 tumour m3 and patient E1 tumour m7) display clear positive 2SC staining, whereas tumours harbouring a MED12 mutation and not displaying biallelic FH inactivation (bottom panel; patient B3 tumour m2 and patient E1 tumour m10) are negative.
