Table 3. Clinicopathological features of the 38 tumour relapse samples from APR after initial RT/CRT.
| Total | n=38 |
|---|---|
|
Gender | |
| Female | 29 |
| Male | 9 |
|
Concomitant HIV infection | |
| Yes | 7 |
| No | 31 |
|
HPV status | |
| HPV positive | 34 |
| genotype 16 | 29 |
| other genotypes (6–11/18/33/59) | 5 (1/2/1/1) |
| HPV negative | 4 |
|
Initial therapy before APR | |
| Radiation | 14 |
| Chemoradiation with 5FU-CDDP | 20 |
| Chemoradiation with 5FU-MMC | 3 |
| Chemoradiation with other CT | 1 |
|
Pathological results | |
| Tumour differentiation | |
| Poor | 6 |
| Moderate/well | 32 |
| ypT stage | |
| T0 | 1 |
| T1 | 5 |
| T2 | 19 |
| T3 | 9 |
| T4 | 3 |
| ND | 1 |
| ypN stage | |
| N− | 31 |
| N+ | 7 |
| Vascular emboli | |
| Yes | 8 |
| No | 30 |
| Lymphatic invasion | |
| Yes | 9 |
| No | 29 |
| Perineural invasion | |
| Yes | 10 |
| No | 28 |
| R1 resection | |
| Yes | 8 |
| No | 30 |
|
PIK3CA mutation | |
| Yes | 11 |
| Exon 9 | 10 |
| c.1624G>A;p.E542K | 5 |
| c.1633G>A:p.E545K | 5 |
| Exon 20 | 1 |
| No | 27 |
|
FBXW7 mutation | |
| Yes | 5 |
| No | 33 |
|
TP53 mutation | |
| Yes | 4 |
| No | 34 |
Abbreviations: APR=abdominoperineal resection; CRT=chemoradiotherapy; CT=chemotherapy; HIV=human immunodeficiency virus; HPV=human papilloma virus; ND=not determined; RT=radiotherapy; 5FU-CDDP=5-fluorouracil-cisplatin; 5FU-MMC=5fluorouracil-mitomycin C.