Skip to main content
. 2016 May 24;114(12):1387–1394. doi: 10.1038/bjc.2016.144

Table 3. Clinicopathological features of the 38 tumour relapse samples from APR after initial RT/CRT.

Total n=38
Gender
Female 29
Male 9
Concomitant HIV infection
Yes 7
No 31
HPV status
HPV positive 34
 genotype 16 29
 other genotypes (6–11/18/33/59) 5 (1/2/1/1)
HPV negative 4
Initial therapy before APR
Radiation 14
Chemoradiation with 5FU-CDDP 20
Chemoradiation with 5FU-MMC 3
Chemoradiation with other CT 1
Pathological results
Tumour differentiation  
 Poor 6
 Moderate/well 32
ypT stage  
 T0 1
 T1 5
 T2 19
 T3 9
 T4 3
 ND 1
ypN stage  
 N− 31
 N+ 7
Vascular emboli  
 Yes 8
 No 30
Lymphatic invasion  
 Yes 9
 No 29
Perineural invasion  
 Yes 10
 No 28
R1 resection  
 Yes 8
 No 30
PIK3CA mutation
Yes 11
 Exon 9 10
  c.1624G>A;p.E542K 5
  c.1633G>A:p.E545K 5
 Exon 20 1
No 27
FBXW7 mutation
Yes 5
No 33
TP53 mutation
Yes 4
No 34

Abbreviations: APR=abdominoperineal resection; CRT=chemoradiotherapy; CT=chemotherapy; HIV=human immunodeficiency virus; HPV=human papilloma virus; ND=not determined; RT=radiotherapy; 5FU-CDDP=5-fluorouracil-cisplatin; 5FU-MMC=5fluorouracil-mitomycin C.