Mast cell mediator symptom prevalence by age category. A, Blistering. B, Pruritus. C, Flushing. D, Diarrhea. Within each panel, each dot represents the prevalence for specific age categories (0-1, 1-2, 2-3, 3-4, 4-6, 6-8, 10-12, 12-14, 14-18, and ≥ 18 years), and the red bar is the 95% CI for that prevalence. The blue loess curves illustrate prevalence across age categories when all mastocytosis variants are analyzed collectively. Symptoms were scored as present (1) or not present (0).