Serum tryptase levels over time. Sequential serum tryptase levels in patients with UP (n = 18; nodular maculopapular cutaneous mastocytosis, n = 1; A), DCM (n = 7; B), or ISM (n = 11; C) with at least 18 months of follow-up. Linear regression lines are presented for each patient, along with each observation. Blue lines denote values from patients with complete disease resolution, purple lines denote major resolution, and red lines denote partial resolution. Serum tryptase levels decreased or remained stable over time for all variants. The shaded area represents the tryptase normal range (<11.4 mg/mL).