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2D transformations of predicted docking poses of GRP-71271 analogs to A/Puerto Rico/8/1934 (H1N1) HA (PDB entry 1RU7) with EC50 values of ≤10 μM in biotesting. Analogs are predicted to populate the candidate target site, but interrupted contour plots and large solvent-exposed substructures indicate less favorable docking than that predicted for GRP-71271.
