FIG 3.

The P domain contains a putative Ser-His-Asp active site that is part of a patch of residues that are conserved among iflaviruses. The conserved residues are highlighted in gray in pentamers of capsid protein protomers in the conformation from crystal form 1 (A) and crystal form 2 (B). Detail of the putative active site with electron density contoured at 2σ (C). A sequence alignment of residues forming the conserved patch in the P domain is also shown (D). HEI, heliconius erato iflavirus; API, antherae pernyi iflavirus. Uniprot accession numbers of the sequences used in the alignment are provided.