FIG 9.

Residues of the NS5A anchor helix that are important for HCV RNA replication. The diagram highlights the residues important for HCV RNA replication either individually or in groups, depicted in yellow and red, respectively. Residues that are dispensable for replication are indicated in blue. “N” and “C” indicate the N-terminal and C-terminal ends, respectively. The two arrows perpendicular to each other depict the positioning of the anchor helix along the membrane surface. The NS5A anchor helix structural illustration was prepared by using PyMOL.