TABLE 3.
Summary of CMV-specific peptide epitope recognition by HSCT recipients
| Peptide sequencec | Reactivation |
No reactivation |
|||
|---|---|---|---|---|---|
| No. of HLA-matched recipients | No. of HLA-matched recipients with sequence detected | No. of respondersa | No. of HLA-matched recipients | No. of respondersa | |
| VLEETSVML | 12 | 7 | 3 | 5 | 1 |
| YILEETSVML | 12 | 5 | 4 | 5 | 2 |
| DELRRKMMY | 7 | 5 | 2 | 4 | 0 |
| DELKRKMIY | 7 | 3 | 1 | 4 | 0 |
| EEAIAVAYL | 7 | 4 | 2 | 4 | 0 |
| EDAIAAYTL | 7 | 6 | 0 | 4 | 0 |
| ELRRKMMYM | 2 | 2 | 1 | 2 | 2 |
| ELKRKMIYM | 2 | 1 | 2 | 2 | 2 |
| AYAQKIFKIL | 1 | 0 | 1 | 1 | 0 |
| TYSQKIFKIL | 1 | 1 | 1 | 1 | 1 |
| KARAKKDELR | 1 | 1 | 0 | 1 | 0 |
| KARAKKDELK | 1 | 0 | 0 | 1 | 0 |
| ARAKKDELK | 1 | 1 | 1 | 1 | 0 |
| ARAKKDELR | 1 | 1 | 1 | 1 | 0 |
| KRKMIYMCYR | 1 | 0 | 0 | 1 | 1 |
| RRKMMYMCYR | 1 | 1 | 1 | 1 | 1 |
| FMDILTTCV | 12 | NDb | 5 | 5 | 0 |
| NLVPMVATV | 12 | ND | 8 | 5 | 3 |
| RPHERNGFTVL | 1 | ND | 1 | 1 | 1 |
| TPRVTGGGAM | 1 | ND | 1 | 1 | 1 |
| VTEHDTLLY | 3 | ND | 3 | 4 | 3 |
| QIKVRVDMV | 2 | ND | 1 | 1 | 1 |
| YSEHPTFTSQY | 0 | ND | 0 | 2 | 2 |
a
Patients with >5% of CD8+ T cells producing IFN-γ following recall after 2 weeks of culture were considered responders.
b
ND, not done.
c
Underlining represents variant amino acids.