FIG 6.
Examples of progressor and controller monkeys simulated with the quasi–steady-state version of the three-stage model of equation 21. Progressors are made by giving them just one immune response (with k21 = 10), whereas controllers are given 10 immune responses (with k2i = 10 for i = 1,2,…,10), Performing CD8+ T cell depletion at day 150, we confirm the findings of Chowdhury et al. (15), showing that the viral load increases faster in monkeys that control better. (a) s = dT = 0.1, n = 1: ρ = 0.43 and K2 = 1.4 day−1. (b) s = dT = 0.1, n = 10: ρ = 1.02 and K2 = 3.8 day−1. (c) s = dT = 0.5, n = 1: ρ = 0.88 and K2 = 3.2 day−1. (d) s = dT = 0.5, n = 10: ρ = 1.35 and K2 = 5.4 day−1. (e) Confirmation that all combinations fall on the line predicted by equation 18b. Parameters are for the late killing regime with k2i = 10, and hi = i/1,000 for i = 1,2,…,n, β = 91, d0 = 54, and γ0 = 6 day−1.