Vaccine-induced SIV Env-specific IgA responses prior to SIV challenge. (A) SIV gp140-specific plasma IgA levels at weeks 6 and 9 in naive animals, noncontroller animals, and controller animals. (B and C) gp140-specific IgA activity in saliva and fecal samples of controller and noncontroller animals at week 9. (D to F) Correlation between plasma, salivary, and fecal gp140-specific IgA at week 9 and acute viremia, respectively. (G) Linear positive correlation between salivary and fecal IgA at week 9. (H and I) Lack of correlation between plasma IgA and saliva IgA (H) or fecal IgA (I).