TABLE 2.
Correlations between vaccine-induced antibody responses at week 9 and acute viremia
| Parametera | Spearman correlationb |
||
|---|---|---|---|
| Correlation | r value | P value | |
| IgG | |||
| Plasma anti-SIV Env IgG | |||
| gp140 IgG BAb | NS | 0.2381 | 0.5821 |
| gp120 IgG BAb | NS | −0.0476 | 0.9349 |
| V1V2 IgG BAb | NS | −0.2143 | 0.6191 |
| gp36 IgG BAb | NS | 0.0952 | 0.8401 |
| Fecal anti-SIV Env IgG | |||
| gp140 IgG BAb | Not detectable | NA | NA |
| Plasma Gag, Pol IgG | NS | −0.2143 | 0.6191 |
| Fecal Gag, Pol IgG | Not detectable | NA | NA |
| IgA | |||
| Plasma gp140 IgA BAb | NS | −0.4286 | 0.2992 |
| Salivary gp140 IgA BAb | Inverse | −0.8571 | 0.0107 |
| Fecal gp140 IgA BAb | Inverse | −0.9550 | 0.0028 |
| Plasma Gag, Pol IgA | NS | −0.4048 | 0.3268 |
| Fecal Gag, Pol IgA | Not detectable | NA | NA |
| Function | |||
| Plasma gp140 IgG avidity | Inverse | −0.7381 | 0.0458 |
| Plasma ADP | None | 0.0000 | >0.9999 |
| Plasma ADCVI | <5% (negative) | NA | NA |
| Plasma tier 1 neutralization | None | 0.3995 | 0.3894 |
a
BAb, binding antibody.
b
NS, not significant; NA, not applicable.