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. 2016 Jul 27;90(16):7303–7312. doi: 10.1128/JVI.00539-16

FIG 1.

FIG 1

ALCAM is overexpressed on primary HTLV-1-infected CD4+ T lymphocytes. (A) Percentage of the primary CD4+ T lymphocyte subsets based upon CD25 levels by flow cytometry. Subpopulations correspond to nonactivated CD4+ T cells (CD25−, in black) or activated CD4+ T cells (CD25+, in blue). The CD25++ subpopulation (in red) corresponds to Tregs in healthy donors (HDs) and mostly HTLV-1-infected cells in HTLV-1-infected asymptomatic carriers (HACs) and HAM/TSP patients. (B) The percentage of CD4+ CD25++ cells correlates with proviral load. Proviral load was calculated as a number of copies of Tax for 100 CD4+ T cells. Spearman's correlation test was significant (P < 10−4; Spearman's correlation coefficient [rs] = 0.9796). (C) Mean fluorescence intensity (MFI) of CD6 on the different CD25-based subpopulations. (D) ALCAM MFI on the different CD25-based subpopulations.