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. 2016 Mar 31;114(8):863–871. doi: 10.1038/bjc.2016.82

Table 1. Patient baseline demographic data and clinical characteristics.

  EC-Doc FEC120
Variable n=689 n=675
Age, years
Median (range) 54 (27–71) 54 (25–71)
Mean (s.d.) 53.3 (9.95) 53.9 (9.85)
Body mass index, kg m−2
Median (range) 25.9 (15.6–53.5) 25.9 (16.9–48.2)
Mean (s.d.) 26.8 (5.2) 26.8 (4.9)
Menopausal status, n (%)
Premenopausal 252 (36.6) 253 (37.5)
Postmenopausal 428 (62.1) 417 (61.8)
Unknown 9 (1.3%) 5 (0.7)
ECOG performance status, n (%)
0 298 (43.3) 274 (40.6)
1 294 (42.7) 303 (44.9)
2 45 (6.5) 49 (7.3)
3 3 (0.4) 1 (0.1)
4 4 (0.6) 3 (0.4)
Unknown 45 (6.5) 45 (6.7)
Histological subtype, n (%)
Ductal 486 (70.5) 467 (69.2)
Lobular 144 (20.9) 142 (21.0)
Mixed ductal-lobular 53 (7.7) 60 (8.9)
Undefined 6 (0.9) 6 (0.9)
Tumour location, n (%)
Left 340 (49.3) 343 (50.8)
Right 344 (49.9) 331 (49.0)
Unknown 5 (0.7) 1 (0.1)
Tumour size, n (%)
T1 189 (27.4) 199 (29.5)
T2 393 (57.0) 355 (52.6)
T3 84 (12.2) 81 (12.0)
T4 22 (3.2) 38 (5.6)
Unknown 1 (0.1) 2 (0.3)
Number of positive axillary lymph nodes, n (%)
1–3 (pN1) 1 (0.1) 3 (0.4)
4–9 (pN2) 417 (60.5) 405 (60.0)
⩾10 (pN3) 270 (39.2) 265 (39.3)
Unknown 1 (0.1) 2 (0.3)
Histological grade, n (%)
Grade 1+2 346 (50.2) 340 (50.4)
Grade 3 300 (43.5) 274 (40.6)
Unknown 43 (6.2) 61 (9.0)
Hormone receptor status, n (%)
Negative 170 (24.7) 162 (24.0)
Positive 519 (75.3) 513 (76.0)
HER2 status, n (%)
Negative 476 (69.1) 473 (70.1)
Positive 149 (21.6) 153 (22.7)
Undefined 64 (9.3) 49 (7.3)
Additional treatment, n (%)
Radiotherapy after chemotherapy 591 (85.8) 570 (84.4)
Radiotherapy between chemotherapy courses 98 (14.2) 105 (15.6)
Endocrine treatment 84 (12.2) 73 (10.8)

Abbreviations: ECOG=European Co-operative Oncology Group; EC-Doc=epirubicin/cyclophosphamide followed by docetaxel; FEC=fluorouracil/epirubicin/cyclophosphamide.