Table 2.
Mean change in outcome measures and 95% CI compared to baseline# by intervention group at 16 and 24 weeks [intention-to-treat (ITT)]
| Assessment week | ||||||
|---|---|---|---|---|---|---|
| 16 | 24 | |||||
| Group† | PR | ST+PR | ST+SM+PR | PR | ST+PR | ST+SM+PR |
| Systolic BP | −3·6 (−13·5, 6·3) | −10·6 (−19·6, −1·5) | −8·3 (−20·5, 3·8) | −7·1 (−17·3, 3·0) | −6·9 (−15·8, 2·1) | −10·1(−25·6, 5·4) |
| Diastolic BP | −3·5 (−12·6, 5·6) | −7·7 (−17·1, 1·8) | −4·7 (−13·5, 4·2) | −4·7 (−13·3, 4·0) | −8·1 (−17·8, 1·5) | −8·0 (−19·6, 3·6) |
| FEV1 (l) | −0·042 (−0·113, 0·029) | −0·021 (−0·115, 0·072) | −0·020 (−0·136, 0·096) | −0·077 (−0·164, 0·011) | −0·089 (−0·175, −0·003) | −0·020 (−0·144, 0·104) |
| FVC (l) | 0·10 (−0·14, 0·35) | 0·45 (0·13, 0·77) | 0·37 (0·22, 0·53) | 0·10 (−0·14, 0·34) | 0·32 (−0·05, 0·68) | 0·53* (0·26, 0·81) |
| SGRQ | −4·6 (−9·8, 0·5) | −0·7 (−7·2, 5·8) | −3·3 (−16·3, 9·7) | −8·1 (−14·6, −1·6) | 1·0 (−3·5, 5·5) | −4·3 (−19·9, 11·3) |
| HAD anxiety | −0·1 (−1·5, 1·3) | −0·3 (−2·4, 1·8) | 0·5 (−0·7, 2·0) | −0·9 (−2·8, 1·1) | −0·8 (−3·7, 2·2) | 0·2 (−1·3, 1·7) |
| HAD depression | −0·9 (−1·7, −0·2) | −1·3 (−3·8, 1·1) | −1·9 (−4·2, 2·2) | −1·3 (−2·1, −0·4) | −0·8 (−2·7, 1·2) | −0·7 (−4·4, 3·1) |
| 6MWT (m) | 22·7 (−6·1, 51·4) | 5·8 (−25·1, 36·7) | 51·7 (29·8, 73·6) | 12·1 (−18·0, 42·2) | −16·4 (−55·1, 22·2) | 35·0 (−1·5, 71·5) |
#
See Table 1 for baseline values.
†
Pulmonary rehabilitation (PR): group 1; soft tissue therapy+pulmonary rehabilitation (ST+PR): group 2; soft tissue therapy+spinal manipulation+pulmonary rehabilitation (ST+SM+PR): group 3.
BP: blood pressure; FEV1: forced expiratory volume in 1st second; FVC: forced vital capacity; SGRQ: St George’s respiratory questionnaire; HAD: hospital anxiety and depression scale; 6MWT: 6-minute walking test.
*
Statistically significantly different (P = 0·04).