Table 2. Treatment received by patients before and after brain metastasis and impact on times to progression and survival.

	Chemotherapy		Hormone therapy		HER2-directed therapy
Number of treatments	Number	Median time to brain metastases	Number	Median time to brain metastases	Number	Median time to brain metastases
(a) Treatment received by patients before diagnosis of brain metastasis and median time (months) to brain metastasis from breast cancer diagnosis comparing treatment with no treatment
0	9	28	18	21.5	23	23
1	20	23	10	27.5	12	26
2	4		6		0
3	2		0		0
4	1		0		0
Unknown	5		7		6

	Chemotherapy		Hormone therapy		HER2-directed therapy
Number of treatments	Number	Median survival	Number	Median survival	Number	Median survival
(b) Treatment received by patients after diagnosis of brain metastasis and median overall survival (months) from brain metastasis comparing treatment with no treatment
0	27	10	26	13.5	34	16.5
1	6	33.5	7	16.5	1	6
2	0		1		0
3	1		0		0
4	1		0		0
Unknown	6		7		6