Table 2. Estimated ORs and 95% CIs for the association of analgesic medication use and ovarian cancer risk.

Analgesic medication use
	No. of cases (n=541)	No. of controls (n=731)	Adjusted ORa (95% CI)
Never users	362	467	1.00 (Referent)
Any NSAIDb only	125	197	0.73 (0.54–0.98)
Acetaminophen only	23	33	0.98 (0.53–1.81)
Both NSAIDs and acetaminophen	31	34	1.03 (0.58–1.84)
Aspirin use
	No. of cases (n=432)	No. of controls (n=560)	Adjusted ORa,c (95% CI)
Never users	362	467	1.00 (Referent)
Ever use	70	93	0.56 (0.35–0.92)
Non-aspirin NSAID use
	No. of cases (n=474)	No. of controls (n=628)	Adjusted ORa,c (95% CI)
Never users	362	467	1.00 (Referent)
Ever use	112	161	0.74 (0.52–1.05)
Acetaminophen use
	No. of cases (n=416)	No. of controls (n=534)	Adjusted ORa,c (95% CI)
Never users	362	467	1.00 (Referent)
Ever use	54	67	0.89 (0.49–1.62)

Abbreviations: CI=confidence interval; NSAID=nonsteroidal anti-inflammatory drug; OR=odds ratio.

^aAdjusted for age, study site, education, income, parity, family history of first-degree relative with breast or ovarian cancer, tubal ligation, body mass index (BMI), oral contraceptive use, menopausal status, endometriosis, pelvic inflammatory disease, and physical activity.

^bAny NSAID use includes aspirin and non-aspirin NSAIDs, but not acetaminophen.

^cAlso simultaneously adjusted for use of other analgesics.