Table I.

Composition of Hydrogel

Ingredients	% of ingredients (w/w)
	Hydrogel with nanosize drug without enhancer	Hydrogel with nanosize drug with enhancer	Hydrogel with microsize drug without enhancer	Hydrogel with microsize drug with enhancer
Polyvinyl alcohol	5.8	5.8	5.8	5.8
Carbopol 71G	1.5	1.5	1.5	1.5
Diclofenac diethylamine	1.1	1.1	1.1	1.1
Triethanolamine	–	1.9	–	1.9
Ethanol (95%)	2 mL	2 mL	–	–
Water	98 mL	98 mL	100 mL	100 mL
Sodium hydroxide solution (2% w/v)	Few drops	Few drops	Few drops	Few drops

Batch size 100 g