Table VI.

Saturation Solubility (C _S) and Relative Sink Conditions (S Value) of Carvedilol in Dissolution Media. Data are Presented as the Mean ± SD (n = 3)

Dissolution media	pH	Solubility (C S, μg/mL)	S value (C S/C D a)
0.7% HCl	1.45	545.1 ± 5.0	19.6
SGFsp	1.2	832.0 ± 66.0	29.9
Blank FaSSGF	1.6	2398.6 ± 40.9	86.3
Blank FeSSGF	5.0	995.6 ± 20.5	35.8
Acetate buffer	4.5	2591.4 ± 35.8	93.2
Blank FaSSIF	6.5	51.6 ± 5.5	1.9
Blank FeSSIF	5.0	830.7 ± 17.4	29.9
SIFsp	6.8	51.1 ± 3.0	1.8
Phosphate buffer (IntPh3)	6.8	51.9 ± 5.8	1.9
Phosphate buffer 6.25 mM	6.8	52.5 ± 4.2	1.9
Phosphate buffer 12.5 mM	6.8	53.5 ± 1.1	1.9
Phosphate buffer 25 mM	6.8	31.8 ± 1.9	1.1
Phosphate buffer 50 mM	6.8	31.5 ± 1.0	1.1
Phosphate buffer 100 mM	6.8	34.3 ± 0.7	1.2
Phosphate buffer 100 mM	7.2	19.1 ± 1.5	0.7
Phosphate buffer 100 mM	7.8	5.8 ± 0.5	0.2
Double-distilled water	6.5	27.9 ± 3.9	1.0

^a C _D = 27.8 μg/mL