Table II.

Pharmacokinetic Parameters of Odn Suspensions and Odn-CICs Nanosuspensions After Oral Administration to Rats at a Dose of 50 mg/kg (n = 6, mean ± SD)

Parameters	Odn suspensions	Odn-CICs nanosuspensions
C max (μg/mL)	0.589 ± 0.253	1.565 ± 0.406**
T max (h)	0.625 ± 0.250	0.750 ± 0.288
T 1/2 (h)	13.405 ± 3.867	5.035 ± 1.639**
AUC0-t (μg/h/mL)	2.609 ± 4.84	5.557 ± 1.321**
RBA (%)	/	213.99

ODN oridonin, CICs cyclodextrin inclusion complexes, AUC area under the plasma Odn concentration–time curve, RBA relative bioavailability

One-way ANOVA, **P < 0.01, compared with the reference of Odn suspensions