Table III.

Pharmacokinetic Parameters of Erlotinib in Rats After Oral Administration of Erlotinib Powder and the SEDDS Formulations

Parameters	Powder	SEDDS prepared with dextran 40	SEDDS prepared with Aerosil® 200
T max (h)	3.75 ± 0.50	3.00 ± 0.82	3.75 ± 0.50
C max (μg/mL)	0.36 ± 0.12	0.85 ± 0.12*	1.52 ± 0.15*,**
AUC0-∞ (h·μg/mL)	4.34 ± 1.20	9.06 ± 2.02*	15.26 ± 0.66*,**
k el (h−1)	0.04 ± 0.02	0.09 ± 0.03	0.11 ± 0.01
t 1/2 (h)	18.89 ± 7.09	7.85 ± 1.99	6.37 ± 0.17

Each value represents the mean ± S.D. (n = 4)

SEDDS self-emulsifying drug delivery system, C _max maximum concentration, T _max time for the occurrence of C _max, AUC area under the curve, k _el elimination rate constant, t _1/2 elimination half-life

*p < 0.05 compared with erlotinib powder; **p < 0.05 compared with SEDDS prepared with dextran 40