Table 3. Time-dependent overall survival analysis (crude RR and adjusted RR) for non-users and users of aspirin or NSAIDs.

	N	Ea	Crude rate ratio	P-value	Adjusted rate ratiob	P-value
Aspirin pre and postdiagnosis
Non-user	157	129	Reference	<0.001	Reference	<0.001
User	89	67	0.55 (0.41–0.74)		0.44 (0.31–0.61)
Aspirin only postdiagnosis
Non-user	157	129	Reference	<0.001	Reference	0.006
User	16	7	0.15 (0.07–0.32)		0.29 (0.12–0.70)
Aspirin postdiagnosisc
Non-user	157	129	Reference	<0.001	Reference	<0.001
User	105	74	0.45 (0.34–0.60)		0.42 (0.30–0.57)
Non-user	215	171	Reference	0.003	Reference	<0.001
Frequent user (>30)	47	32	0.56 (0.39–0.82)		0.49 (0.33–0.73)
Non-user	237	188	Reference	0.002	Reference	<0.001
Frequent user (>45)	25	15	0.43 (0.25–0.73)		0.36 (0.21–0.62)
Non-user	248	196	Reference	<0.001	Reference	<0.001
Frequent user postdiagnosis (>20)	14	7	0.23 (0.11–0.50)		0.25 (0.11–0.54)
NSAID pre and postdiagnosis
Non-user	157	129	Reference	<0.001	Reference	0.02
User	204	146	0.45 (0.36–0.57)		0.72 (0.55–0.95)
NSAID only postdiagnosis
Non-user	157	129	Reference	0.05	Reference	0.2
User	94	76	0.75 (0.57–1.00)		0.81 (0.59–1.11)
NSAID postdiagnosisc
Non-user	157	129	Reference	<0.001	Reference	0.2
User	298	222	0.61 (0.49–0.76)		0.84 (0.66–1.07)

Abbreviations: NSAIDs, nonsteroidal anti-inflammatory drugs; RR, rate ratio.

^aE=number of events.

^bAdjusted for sex, age, grade, stage, morphology, histological type, location of the tumour, treatment and comorbidities.

^cPre and postdiagnosis and only postdiagnosis users combined.