Figure 3.

The protein and mRNA expression levels of IRs-1 in primary cultured cardiomyocytes. The protein and mRNA expression level of IRs-1 was significantly reduced by atorvastatin and showed a negative correlation with the concentration. No significant difference was observed in pravastatin and rosuvastatin groups. OB – the cardiomyocytes without treatment; S1 – the cardiomyocytes treated with insulin; S2 – the cardiomyocytes treated with insulin and 1-μM statins; S3 – statins the cardiomyocytes treated with insulin and 5-μM statins; S4 – the cardiomyocytes treated with insulin and 1-μM statins. * P<0.05 compared with S1 group; ^# P<0.05 compared with S2 group.