Table 2. Vaccine Effectiveness of PCV13 among children under two years of age with IPD in Germany, July 2010 till June 2015.

Values in bold are statistically significant.

2010–2015		cases vaccinated: unvaccinated	controls vaccinated: unvaccinated	crude vaccine effectiveness (95% CI)	adjusted vaccine effectiveness (95% CI)
PCV13 serotypes
	at least one dose	25:55	194:43	90% (82 to 94)	86% (74 to 93)
	post primary	10:22	74:20	87% (70 to 95)	85% (62 to 94)
	post booster	2:13	33:16	91% (65 to 98)	91% (61 to 99)
PCV13-non-PCV7 serotypes
	at least one dose	23:43	194:43	88% (78 to 93)	82% (66 to 91)
	post primary	10:16	74:20	82% (57 to 93)	80% (46 to 93)
	post booster	2:12	33:16	90% (62 to 98)	90% (54 to 98)
PCV7 serotypes in PCV13
	at least one dose	2:12	194:43	96% (84 to 99)	94% (78 to 99)
	post primary	0:6	74:20	98% (81 to 100)	99% (80 to 100)
	post booster	0:1	33:16	84% (-225 to 100)	83% (-240 to 100)
Serotype 1
	at least one dose	2:5	194:43	90% (56 to 98)	83% (15 to 97)
	post primary	1:2	74:20	84% (-31 to 99)	49% (-614 to 96)
	post booster	0:1	33:16	84% (-225 to 100)	82% (-328 to 100)
Serotype 3
	at least one dose	6:5	194:43	74% (10 to 92)	74% (2 to 93)
	post primary	1:2	74:20	84% (-31 to 99)	80% (-68 to 98)
	post booster	1:2	33:16	70% (-140 to 97)	63% (-393 to 97)
Serotype 5
	at least one dose	0:0	194:43
	post primary	0:0	74:20
	post booster	0:0	33:16
Serotype 6A
	at least one dose	0:4	194:43	95% (55 to 100)	96% (56 to 100)
	post primary	0:1	74:20	91% (-78 to 100)	84% (-214 to 100)
	post booster	0:2	33:16	90% (-30 to 100)	84% (-224 to 100)
Serotype 7F
	at least one dose	1:12	194:43	97% (88 to 100)	84% (18 to 98)
	post primary	0:2	74:20	95% (29 to 100)	86% (-116 to 100)
	post booster	0:0	33:16	51% (-9185 to 100)	32% (-8066 to 99)
Serotype 19A
	at least one dose	14:17	194:43	81% (60 to 92)	77% (47 to 90)
	post primary	8:9	74:20	75% (30 to 92)	73% (18 to 92)
	post booster	1:7	33:16	90% (49 to 99)	88% (25 to 99)