Table 1. Comparison of clinical characteristics of synchronous multiple lung adenocarcinomas (SMLA) versus Control (single-tumor lung adenocarcinoma cases).
| Variables | SMLA | Control | P value | |
|---|---|---|---|---|
| Age(mean±SD) | 71.1±5.6 | 71.3±7.1 | N.S. | |
| Smoking history | negative | 27 (90) | 78 (98.7) | |
| positive | 3 (10) | 1 (1.3) | N.S. | |
| Pathological stage | IA | 29 | 62 | |
| IB | 1 | 9 | ||
| IIA | 0 | 3 | ||
| IIB | 0 | 1 | ||
| IIIA | 0 | 4 | N.S. | |
| EGFR mutation | negative | 13 (43.3) | 32 (40.5) | |
| positive | 17 (56.7) | 47 (59.5) | N.S. | |
| Familial history of lung cancer | negative | 24 (80) | 68 (86.1) | |
| positive | 6 (20) | 11 (13.9) | N.S. | |
| SNP rs3764221 of CYP19A1 | AA/AG | 20 (66.7) | 33 (41.8) | |
| GG | 10 (33.3) | 46 (58.2) | 0.03 | |