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. 2016 Aug 15;11(8):e0160910. doi: 10.1371/journal.pone.0160910

Table 1. Comparison of clinical characteristics of synchronous multiple lung adenocarcinomas (SMLA) versus Control (single-tumor lung adenocarcinoma cases).

Variables SMLA Control P value
Age(mean±SD) 71.1±5.6 71.3±7.1 N.S.
Smoking history negative 27 (90) 78 (98.7)
positive 3 (10) 1 (1.3) N.S.
Pathological stage IA 29 62
IB 1 9
IIA 0 3
IIB 0 1
IIIA 0 4 N.S.
EGFR mutation negative 13 (43.3) 32 (40.5)
positive 17 (56.7) 47 (59.5) N.S.
Familial history of lung cancer negative 24 (80) 68 (86.1)
positive 6 (20) 11 (13.9) N.S.
SNP rs3764221 of CYP19A1 AA/AG 20 (66.7) 33 (41.8)
GG 10 (33.3) 46 (58.2) 0.03