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. 2016 Aug 15;11(8):e0161217. doi: 10.1371/journal.pone.0161217

Fig 4. Boosting BCG with H56 improves clinical parameters and dampens infection-driven immune responses after Mtb infection.

Fig 4

A, weight gains post challenge. Lines represent mean +/- SEM of relative weight gains. Weight at the time of challenge was set to 100% for each animal. *, denotes statistical significance when compared to the non-vaccinated group. The non-vaccinated group is depicted by filled circles in all panels against each vaccine group (open triangles). B, erythrocyte sedimentation rate (ESR) post challenge. Lines represent mean +/- SEM values post challenge for each group. For monkeys necropsied prior to the study termination, their weights and ESR-values at the necropsy time point were used for the remainder of the study. Symbols as described in A. C, post challenge ESAT-6 specific responses were assessed by IFN-γ ELISA. Lines represent mean +/- SEM IFN-γ production of triplicate whole blood cultures stimulated with ESAT-6, with background (media control) deducted. It should be noted that only one non-vaccinated monkey survived after week 27, hence the lack of error bars in C after this time point. *, denotes statistical significance when compared to the non-vaccinated group. Comparisons were done for weeks 0–21 only since later time points only included one animal in the non-vaccinated group. Symbols as described in A.