Table 3. Characteristics of eligible patients 10 years after start of ART, together with unadjusted and adjusted hazard ratios (HR).
| Characteristics | Number (%) of patients | Number (%) of deaths | Unadjusted HR | Adjusted HR |
|---|---|---|---|---|
| (95% CI) | (95% CI)* | |||
| Total | 13,011 (100%) | 656 (100%) | ||
| Risk group | ||||
| IDU (vs non-IDU) | 1,636 (13%) | 121 (7%) | 2.54 (2.03, 3.18) | 2.58 (2.04, 3.26) |
| Sex | ||||
| Female (vs male) | 2,701 (21%) | 81 (3%) | 0.76 (0.60, 0.96) | 0.95 (0.74, 1.21) |
| AIDS diagnosis | ||||
| No AIDS | 8,661 (67%) | 302 (3%) | 1 | 1 |
| AIDS before ART start | 2,714 (21%) | 175 (6%) | 1.73 (1.43, 2.09) | 1.48 (1.23, 1.80) |
| AIDS between ART start and 10 years afterwards | 1,636 (13%) | 179 (11%) | 2.14 (1.75, 2.62) | 1.68 (1.37, 2.06) |
| Age (years) | ||||
| Median (IQR) | 46 (41, 53) | |||
| 16–39 | 2,330 (18%) | 53 (2%) | 1 | 1 |
| 40–49 | 6,029 (46%) | 225 (4%) | 1.50 (1.11, 2.03) | 1.40 (1.04, 1.90) |
| 50–59 | 3,129 (24%) | 200 (6%) | 2.15 (1.58, 2.92) | 2.14 (1.56, 2.92) |
| 60–69 | 1,181 (9%) | 123 (10%) | 3.39 (2.44, 4.71) | 4.29 (3.06, 6.02) |
| ≥70 | 342 (3%) | 55 (16%) | 6.18 (4.22, 9.04) | 8.59 (5.82, 12.7) |
| CD4 count (cells/μL) | ||||
| Median (IQR) | 550 (372, 760) | |||
| ≥750 | 3,396 (26%) | 92 (3%) | 1 | 1 |
| 500–749 | 4,093 (31%) | 126 (3%) | 1.12 (0.85, 1.46) | 1.01 (0.78, 1.33) |
| 350–499 | 2,644 (20%) | 128 (5%) | 1.72 (1.32, 2.25) | 1.41 (1.07, 1.84) |
| 200–349 | 1,850 (14%) | 131 (7%) | 2.37 (1.81, 3.10) | 1.80 (1.37, 2.37) |
| 100–199 | 628 (5%) | 81 (13%) | 4.28 (3.16, 5.78) | 3.07 (2.24, 4.19) |
| 0–99 | 400 (3%) | 98 (25%) | 9.25 (6.90, 12.4) | 6.17 (4.46, 8.53) |
| Viral load (HIV-1 RNA copies/mL) | ||||
| Median (% with RNA≤50) | 50 (75%) | |||
| 0–50 | 9,814 (75%) | 370 (4%) | 1 | 1 |
| 51–1000 | 1,690 (13%) | 119 (7%) | 1.25 (1.00, 1.56) | 1.09 (0.87, 1.36) |
| >1000 | 1,507 (12%) | 167 (11%) | 2.41 (1.99, 2.91) | 1.74 (1.40, 2.15) |
IDU: injection drug use; IQR: inter-quartile range; CI: confidence interval
*Models adjusted for all variables in table, stratified by cohort.