Table 4. Unadjusted and adjusted hazard ratios (HR) according to CD4 count at start of ART and at 10 years after start of ART.
| Cells/μL | N (%) | Unadjusted HR (95% CI) | Adjusted HR (95% CI)* | |
|---|---|---|---|---|
| CD4 count at start of ART (cells/μL) | ≥350 | 4,296 (33%) | 1 | 1 |
| 200–349 | 3,372 (26%) | 1.09 (0.88, 1.35) | 0.96 (0.77, 1.19) | |
| 100–199 | 2,120 (16%) | 1.38 (1.09, 1.73) | 0.94 (0.74, 1.20) | |
| 50–99 | 1,229 (9%) | 1.60 (1.24, 2.08) | 0.88 (0.67, 1.16) | |
| 0–49 | 1,994 (15%) | 1.19 (0.94, 1.52) | 0.69 (0.52, 0.90) | |
| CD4 10 years after start of ART (cells/μL) | ≥750 | 3,396 (26%) | 1 | 1 |
| 500–749 | 4,093 (31%) | 1.11 (0.85, 1.46) | 1.04 (0.80, 1.37) | |
| 350–499 | 2,644 (20%) | 1.72 (1.32, 2.25) | 1.47 (1.12, 1.93) | |
| 200–349 | 1,850 (14%) | 2.37 (1.81, 3.10) | 1.92 (1.45, 2.54) | |
| 100–199 | 628 (5%) | 4.28 (3.16, 5.78) | 3.33 (2.42, 4.60) | |
| 0–99 | 400 (3%) | 9.25 (6.90, 12.40) | 6.85 (4.89, 9.60) |
CI: Confidence interval
*Adjusted for sex, regimen, age (16–39, 40–49, 50–59, 60–69, ≥70 years), mode of transmission (IDU or not), HIV-1 RNA levels 10 years after start of ART (0–50, 51–1000, >1000 copies/ml), AIDS status and mutually adjusted for both CD4 measurements and stratified by cohort.