Figure 6. Comparison of the stemness pathway hallmarks across all 7 patient samples.

Patient-specific networks were developed from the stemness pathway hallmarks and revealed distinct regions of the network were differentially activated across the CRPC patient samples. This suggests that while the stemness pathway hallmarks were enriched in all the patients evaluated, a patient-specific evaluation is needed to determine the precise targets for therapy. Genes and edges that are not represented in the patient-specific network but are in the scaffold network are shown in light grey.