Table 1.
Baseline characteristics of the included studies
| Study characteristics |
Image quality |
Routine dose group |
Reduced dose group |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Study | Total number of patients | IR technique | Noise | CNR | SNR | Subjective image quality | BMI (routine dose group, kg m−2) | Number of patients | Tube current | Tube voltage (kV) | Mean effective dose (normal, mSv) | BMI (reduced dose group, kg m−2) | Number of patients | Tube current | Tube voltage (kV) | Mean effective dose (reduced, mSv) | |
| Renker et al14 | 24 | IRIS | Somatom® Definition Flash | + | NR | NR | + | 30.7 | 12 | NR | 120 | 9.6 | 30.2 | 12 | NR | 80/100 | 3.7 |
| Wang et al15 | 78 | SAFIRE | Somatom Definition Flash | ± | ± | ± | ± | 31.7 | 39 | 354–430 mAs | 120 | 8.8 | 32.3 | 39 | 286–370 mAs | 100 | 4.4 |
| Tomizawa et al16 | 100 | AIDR | Aquilion One™ | + | ± | ± | ± | 24.0 | 50 | 483 mA | 120 | 5.5 | 23.9 | 50 | 289 mA | 120 | 4.2 |
| Hou et al13 | 110 | iDose | Brilliance iCT | ± | ± | ± | ± | 25.1 | 21 | 210 mAs | 120 | 3.2 | 25.5 | 16 | 65 mAs | 120 | 0.9 |
| Gebhard et al17 | 70 | ASIR | Discovery™ HD 750 | + | ± | ± | + | 33.8 | 35 | 646 mA | 116 | 2.5 | 32.9 | 35 | 633 mA | 112 | 2.3 |
| Yin et al18 | 60 | SAFIRE | Somatom Definition Flash | ± | ± | ± | ± | NR | 60 | 320–400 mAs | 80–120 | 1.5 | NR | 60 | 160–200 mAs | 80–120 | 0.7 |
| Carrascosa et al19 | 200 | iDose | Brilliance iCT | ± | NR | NR | ± | 27.2 | 100 | 203 mAs | 119 | 4.6 | 26.3 | 100 | 196 mAs | 109 | 2.8 |
| Takx et al20 | 20 | SAFIRE | Somatom Definition Flash | − | − | − | − | 33.1 | 20 | 331 mAs | 100–120 | 5.5 | 33.1 | 20 | 66 mAs | 100–120 | 1.1 |
| Shen et al21 | 338 | ASIR | Discovery HD 750 | ± | NR | − | + | 25.5 | 109 | 600 mA | 120 | 2.9 | 25.2 | 116 | 300 mA | 120 | 1.8 |
| Fuchs et al22 | 42 | ASIR/MBIR | Discovery HD 750 | + | NR | + | ± | 25.2 | 42 | 450–700 mA | 100–120 | 1.2 | 25.2 | 42 | 150–210 mA | 80–100 | 0.2 |
−, decreased with IR; +, improved with IR; ±, no difference; AIDR, Adaptive Iterative Dose Reduction; BMI, body mass index; CNR, contrast-to-noise ratio; IR, iterative reconstruction; IRIS, Iterative Reconstruction in Image Space; MBIR, Model-Based Iterative Reconstruction; NR, not reported; SAFIRE, Sinogram-Affirmed Iterative Reconstruction; SNR, signal-to-noise ratio.
The Somatom Definition Flash was obtained from Siemens Medical Systems, Forchheim, Germany; Aquilion One™ was obtained from Toshiba Medical Systems Co. Ltd, Ottowara, Japan; Brilliance iCT was obtained from Philips Healthcare, Best, Netherlands; Discovery™ HD 750 was obtained from GE Healthcare, Milwaukee, WI.