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. Author manuscript; available in PMC: 2016 Aug 15.
Published in final edited form as: Transl Perioper Pain Med. 2016;1(2):24–32.

Figure 2. IL-33/ST2 signaling participates in various types of lung injury.

Figure 2

IL-33 /ST2 signaling activation followed by type-2 innate immunity activation, Th2-associated airway inflammation, group 2 innate lymphoid cell (ILC2) activation, eosinophil infiltration, IL-8 up-regulation, mast cell activation and pro-inflammation response, further participates in lung inflammation and allergy, acute lung injury (ALI) and ventilator-induced lung injury (VILI), chronic obstructive pulmonary disease (COPD), lung cancer and pulmonary sarcoidosis and other kinds of lung injury.