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. 2016 Aug 15;27(16):2542–2553. doi: 10.1091/mbc.E16-03-0163

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© 2016 Li, Miao, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 3: — Regulation of Orai1 assembly and selectivity by α-SNAP is independent of Stim1 levels. (A) Representative photobleaching steps obtained from Stim1-mEos–expressing, store- depleted Stim1^−/− MEF cells. (B) Histogram showing number of Stim1-mEos photobleaching steps vs. normalized frequency from store-depleted Stim1^−/− MEFs treated with SCR or α-SNAP siRNA (600–700 spots). (C, D) Box-and-whisker plots of constitutive calcium (C) and sodium influx (D) measured from SCR or α-SNAP siRNA–treated Orai1^−/− MEF cells transfected with Orai1-SS (40–70 cells). Top and bottom box boundaries represent 25th and 75th percentile values, respectively, the median is represented by a horizontal line within the box, and whiskers denote extreme 25% quartile values of the data. Student’s t-test p < 0.0001 (C) and 0.0175 (D).