Table 1.

Optimization of Reaction Parameters^[a]

entry	substrate	conc(M)	Ni mol %	base	additive	yield (%)[b]
1[c]	4a	0.02	50	Et3N (10 equiv)	–	53
2[c]	4b	0.02	50	Et3N (10 equiv)	–	42
3[c]	4a	0.02	35	Et3N (10 equiv)	–	42[d]
4[c]	4a	0.02	35	Cs2CO3 (3.0 equiv)	–	30[d]
5[c]	4a	0.02	35	K3PO4 (3.0 equiv)	–	34[d]
6	4b	0.10	20	Et3N (1.0 equiv)	DABCO (1.0 equiv)	69
7	4b	0.10	20	Et3N (1.0 equiv)	CsF (1.0 equiv)	51
8	4a	0.04	20	DABCO (1.0 equiv)	–	24
9	4a	0.04	20	DABCO (2.0 equiv)	–	50[d]
10	4b	0.15	5	Et3N (1.1 equiv)	Zn (2.0 equiv)	84

^[a]Reactions were performed in a N₂-filled glove box.

^[b]Yield of isolated product.

^[c]DMF (0.04 M) was used as a co-solvent.

^[d]The reaction proceeded with incomplete conversion of starting material.