Table 2.

Effects of Nicotine and Viral Proteins on Immune-Related Genes in the Nucleus Accumbens of the F344 and HIV-1Tg Rats

Gene Symbol	F344 rat (n=5–6 animals)				HIV-1Tg rat (n=5–6 animals)				Viral effect
	Sal (Mean ± SD)	Nic (Mean ± SD)	Ratio Nic/Sal	Nic effect in F344 (P-value)	Sal (Mean ± SD)	Nic (Mean ± SD)	Ratio Nic/Sal	Nic effect in HIV-1Tg (P-value)	Ratio HIV-1Tg_Sal/ F344_Sal	P-value
CASP3	8.1±0.8	11.4±2.9	1.41	0.039	11.6±1.8	11.2±2.8	0.97	0.756	1.43	0.003
CCL3	0.085±0.018	0.15±0.041	1.76	0.005	0.15±0.074	0.20±0.11	1.33	0.443	1.76	0.054
CCL5	0.25±0.0.044	0.21±0.16	0.84	0.531	0.15±0.046	0.18±0.10	1.17	0.97	0.60	0.007
CCL11	0.034±0.023	0.061±0.027	1.81	0.127	0.0164±0.0062	0.051±0.027	3.08	0.023	0.48	0.149
CCR2	0.077±0.027	0.054±0.016	0.71	0.137	0.065±0.020	0.191±0.082	2.92	0.012	0.84	0.463
CX3CL1	275.1±64.8	297.3±90.7	1.08	0.635	359.9±36.3	259.2±44.1	0.72	0.003	1.31	0.029
CX3CR1	38.7±6.6	32.8±5.5	0.85	0.126	28.2±5.3	28.1±4.3	0.99	0.958	0.73	0.012
IL1α	0.288±0.055	0.185±0.070	0.64	0.023	0.12±0.031	0.204±0.049	1.69	0.006	0.42	7.17E-05
IL2	0.29±0.014	0.36±0.14	1.21	0.468	0.305±0.084	0.193±0.0792	0.63	0.040	1.05	0.937
IL5	0.035±0.006	0.076±0.04	2.13	0.037	0.064±0.054	0.075±0.061	1.16	0.759	1.83	0.273
IL8Rα	0.14±0.06	0.232±0.13	1.59	0.184	0.20±0.049	0.10±0.019	0.52	0.002	1.43	0.114
IL17β	0.062±0.046	0.069±0.04	1.11	0.781	0.056±0.015	0.031±0.014	0.56	0.017	0.90	0.77
IRF4	1.2±0.1	1.6±0.3	1.33	0.026	1.9±0.2	1.3±0.5	0.68	0.041	1.58	0.024
IRF7	0.82±0.13	1.4±0.9	1.70	0.109	1.6±0.03	2.1±0.5	1.31	0.142	1.95	2.27E-04
IRF9	8.1±0.8	11.4±2.2	1.41	0.002	9.2±1.4	8.8±2.0	0.96	0.741	1.14	0.139
TGFβ1	3.5±0.3	3.3±0.3	0.94	0.517	3.0±0.2	3.2±0.3	1.01	0.88	0.86	0.023
TLR4	1.73±0.32	1.70±0.31	0.97	0.825	1.32±0.2	1.3±0.1	0.98	0.843	0.76	0.030
TNF	0.32±0.096	0.29±0.062	0.89	0.454	0.25±0.1	0.13±0.065	0.52	0.044	0.78	0.217