Table 3.

Effects of Nicotine and Viral Proteins on Immune-Related Genes in the PFC of the F344 and HIV-1Tg Rat

Gene Symbol	F344 rat (n=5–6 animals)				HIV-1Tg rat (n=5–6 animals)				Viral effect
	Sal (Mean ± SD)	Nic (Mean ± SD)	Ratio Nic/Sal	Nic effect in F344 (P-value)	Sal (Mean ± SD)	Nic (Mean ± SD)	Ratio Nic/Sal	Nic effect in HIV-1Tg (P-value)	Ratio HIV-1Tg_Sal/ F344_Sal	P-value
CASP1	0.25±0.061	0.20±0.062	0.80	0.206	0.30±0.059	0.20±0.026	0.66	0.006	1.20	0.191
CCL2	0.15±0.040	0.080±0.013	0.51	0.004	0.093±0.043	0.078±0.023	0.84	0.476	0.62	0.042
CCL5	0.16±0.064	0.11±0.015	0.689	0.131	0.078±0.022	0.092±0.011	1.19	0.192	0.49	0.026
CCR5	0.014±0.005	0.012±0.0073	0.92	0.752	0.015±0.004	0.010±0.0017	0.66	0.031	1.07	0.72
CX3CR1	21.7±5.69	17.1±2.44	0.79	0.129	19.9±4.66	14.4±2.80	0.72	0.035	0.92	0.548
IL1β	1.48±0.51	1.30±0.42	0.88	0.512	1.59±0.27	1.00±0.31	0.63	0.014	1.07	0.943
IL1R2	0.13±0.021	0.09±0.018	0.68	0.011	0.14±0.034	0.074±0.028	0.53	0.004	1.08	0.615
IL8Rα	0.36±0.060	0.045±0.024	0.12	0.267	0.91±0.81	0.027±0.017	0.30	0.025	2.53	0.254
IL18	2.94±0.95	1.82±0.36	0.63	0.023	2.08±0.85	1.51±0.73	0.73	0.245	0.71	0.133
TGFβ1	2.81±0.38	2.12±0.29	0.76	0.006	2.17±0.37	1.69±0.31	0.74	0.040	0.77	0.015
TLR4	1.60±0.41	1.05±0.25	0.66	0.031	0.87±0.28	0.93±0.16	1.08	0.626	0.54	0.010
TNF	0.18±0.091	0.14±0.058	0.83	0.492	0.14±0.053	0.077±0.043	0.53	0.036	0.78	0.428
TNFRSF1α	3.83±0.47	3.15±0.35	0.82	0.019	3.37±0.72	2.47±0.29	0.73	0.017	0.88	0.225