Table 4.
Effects of Nicotine and Viral Proteins on Immune-Related Genes in the VTA of the F344 and HIV-1Tg Rat
| Gene Symbol | F344 rat (n=5–6 animals) | HIV-1Tg rat (n=5–6 animals) | Viral effect | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Sal (Mean ± SD) | Nic (Mean ± SD) | Ratio Nic/Sal | Nic effect in F344 (P-value) | Sal (Mean ± SD) | Nic (Mean ± SD) | Ratio Nic/Sal | Nic effect in HIV-1Tg (P-value) | Ratio HIV-1Tg_Sal/ F344_Sal | P-value | |
| CASP3 | 6.3±0.83 | 4.61±0.85 | 0.73 | 0.008 | 4.60±0.43 | 4.30±1.12 | 0.94 | 0.556 | 1.37 | 0.001 |
| CCL2 | 0.206±0.053 | 0.137±0.014 | 0.67 | 0.022 | 0.160±0.054 | 0.114±0.047 | 0.71 | 0.150 | 1.29 | 0.169 |
| CCR5 | 0.054±0.027 | 0.045±0.033 | 0.83 | 0.632 | 0.064±0.028 | 0.0196±0.0123 | 0.30 | 0.005 | 0.84 | 0.527 |
| CX3CR1 | 28.2±7.8 | 22.2±0.7 | 0.79 | 0.124 | 19.6±4.8 | 16.5±3.8 | 0.84 | 0.255 | 1.44 | 0.046 |
| IFNα1 | 1.05±0.12 | 1.15±0.18 | 1.10 | 0.283 | 0.79±0.17 | 0.7±0.16 | 0.88 | 0.359 | 1.33 | 0.015 |
| IL1β | 0.470±0.12 | 0.42±0.34 | 0.91 | 0.772 | 0.163±0.050 | 0.15±0.11 | 0.95 | 0.876 | 2.88 | 0.0005 |
| IL5 | 0.097±0.036 | 0.108±0.053 | 1.11 | 0.718 | 0.21±0.11 | 0.088±0.029 | 0.42 | 0.036 | 0.46 | 0.110 |
| IL6 | 0.072±0.055 | 0.0228±0.0368 | 0.31 | 0.192 | 0.28±0.17 | 0.257±0.289 | 0.91 | 0.874 | 0.26 | 0.033 |
| IL8Rα | 0.069±0.017 | 0.30±0.11 | 4.34 | 0.0009 | 0.13±0.10 | 0.062±0.033 | 0.45 | 0.118 | 0.53 | 0.137 |
| IL33 | 8.07±0.73 | 9.49±0.99 | 1.18 | 0.018 | 8.4±2.4 | 8.1±0.7 | 0.96 | 0.79 | 0.96 | 0.757 |
| IRF1 | 3.8±1.6 | 3.7±0.8 | 0.97 | 0.973 | 3.6±1.0 | 2.4±0.3 | 0.67 | 0.032 | 1.06 | 0.836 |
| IRF6 | 0.91±0.26 | 0.53±0.18 | 0.58 | 0.020 | 0.97±0.21 | 1.24±0.63 | 1.28 | 0.353 | 0.94 | 0.710 |
| TNF | 0.2±0.077 | 0.3±0.1 | 1.50 | 0.274 | 0.2±0.069 | 0.1±0.068 | 0.50 | 0.008 | 1.00 | 0.652 |