Table 1.

Radiogenomic studies published in the literature

Study	Year	Country	Data source	Number	Validation set	Cancer	Imaging modality	Number of features	Method of feature extraction	Radiologist involvement	Genomic data	Individual vs clusters	Pathway analysis	Wet-lab validation	Histology correlation	Outcome	Clinical outcomes
Gevaert et al15	2012	USA	Single institutional	26	No	NSCLC	PET	180	Both	Yes	Microarray	Clusters	Yes	No	No	Yes	RFS and OS
Gevaert et al16	2014	USA	TCGA	55	No	GBM	MR	79	Manual	Yes	Microarray, DNA methylation, array CGH	Clusters	Yes	No	No	Yes	PFS and OS
Aerts et al9	2014	Netherlands	Multi-institutional	89	No	NSCLC	CT	440	Semi-automated	No	Microarrays	Clusters	Yes	No	Yes	Yes	OS
Jamshidi et al17	2014	USA	Single institutional	23	No	GBM	MR	6	Manual	Yes	Microarrays, array CGH	Clusters	Yes	No	No	No	NA
Kuo et al18	2007	USA	Single institutional	30	No	HCC	CT	6	Manual	Yes	Microarrays	Clusters	No	No	Yes	No	NA
Nair et al19	2012	USA	Multi-institutional	25	No	NSCLC	PET	14	Semi-automated	Yes	Microarrays	Both	Yes	No	No	Yes	OS
Segal et al20	2007	USA	Single institutional	28	Yes	HCC	CT	138	Manual	Yes	Microarrays	Clusters	Yes	No	Yes	Yes	OS
Yamamoto et al21	2012	USA	Single institutional	10	No	Breast cancer	MR	26	Manual	Yes	Microarrays	Both	Yes	No	No	No	NA
Yamamoto et al22	2015	USA	Single institutional	19	Yes	Breast cancer	MR	47	Semi-automated	Yes	RNA sequencing	Individual	Yes	Yes	Yes	Yes	MFS
Zinn et al23	2011	USA	TCGA	26	Yes	GBM	MR	3	Semi-automated	Yes	mRNA and micro-RNA	Individual	Yes	No	No	Yes	PFS and OS
Barajas et al24	2010	USA	Single institutional	12	No	GBM	MR	9	Manual	Yes	Microarray	Both	Yes	No	Yes	No	NA
Diehn et al25	2008	USA	Single institutional	22	No	GBM	MR	10	Manual	Yes	Microarray	Both	Yes	Yes	No	Yes	OS
Pope et al26	2008	USA	Single institutional	52	No	GBM	MR	1	Manual	Yes	Microarray	Individual	No	Yes	Yes	Yes	OS
Zinn et al27	2012	USA	TCGA	78	Yes	GBM	MR	1	Manual	NA	Microarray and micro-RNA	Individual	Yes	No	No	Yes	OS
Jamshidi et al28	2015	USA	Single institutional	70	Yes	CCRCC	CT	35	Manual	Yes	Microarray	Both	No	No	No	Yes	OS
Colen et al29	2014	USA	TCGA	99	No	GBM	MRI	1	Manual	Yes	Microarray and micro-RNA	Individual	Yes	No	Yes	Yes	OS
Carlson et al30	2007	USA	Single institutional	71	No	HGG	MRI	1	Manual	NA	Microarray	Individual	No	No	No	Yes	OS
Colen et al31	2014	USA	TCGA	104	No	GBM	MRI	30	Manual	Yes	Microarray	Both	Yes	No	No	Yes	OS
Jain et al32	2012	USA	TCGA	18	No	GBM	CT	2	Manual	Yes	Microarray	Individual	Yes	No	No	No	NA
Naeini et al33	2013	USA	Single institutional	46	No	GBM	MRI	3	Manual	NA	Microarray	Clusters	Yes	No	No	Yes	OS
Nicolasjilwan et al34	2015	USA	TCGA	68	Yes	GBM	MRI	30	Manual	NA	Microarrays, array CGH	Clusters	Yes	No	No	No	NA
Pope et al35	2012	USA	Single institutional	38	No	GBM	MRI	1	Manual	Yes	Microarray	Individual	Yes	No	Yes	Yes	OS
Osborne et al36	2010	USA	Single institutional	20	No	Breast cancer	PET	1	Manual	NA	Microarray	Both	Yes	No	Yes	No	NA
Palaskas et al37	2011	USA	Single institutional	18	Yes	Breast cancer	PET	1	Manual	NA	Microarray, array CGH	Clusters	Yes	Yes	Yes	No	NA
Zhu et al38	2015	USA	TCGA and TCIA	91	No	Breast cancer	MRI	38	Semi-automated	NA	Microarray, array CGH, micro-RNA, somatic mutations	Clusters	Yes	No	No	No	NA
Miura et al39	2015	Japan	Single institutional	77	No	HCC	MRI	1	Manual	Yes	Microarray	Individuals	Yes	No	Yes	Yes	PFS and OS
Halle et al40	2012	Norway	Single institutional	46	Yes	Cervical cancer	MRI	1	Manual	Yes	Microarray	Clusters	Yes	Yes	Yes	Yes	PFS

CCRCC, clear-cell renal cell carcinoma; CGH, comparative genomic hybridization; GBM, glioblastoma multiforme; HCC, hepatocellular carcinoma; HGG, high-grade glioma; MFS, metastatic-free survival; NA, not available; NSCLC, non-small-cell lung cancer; OS, overall survival; PET, positron emission tomography; PFS, progression-free survival; RFS, recurrence-free survival; TCGA, The Cancer Genome Atlas; TCIA, The Cancer Imaging Archive.

Article by Colen et al³¹ published in BioMed Central Medical Genomics; article by Colen et al²⁹ published in Radiology.