Table 1.

Effects of exogenous estrogen treatment on cognition in ovariectomized female rodents.^a

Estrogen	Reference	Age (months)	Treatment regimen	Dose	Cognitive outcome	Cognitive effect
17βE2	Luine et al., 2003	2	Acute injection	15 μg/kg	OR, OP	Enhanced
	Daniel and Dohanich, 2001	2	Acute injection	10 μg	RAM	Enhanced
	Gresack and Frick, 2004	6	Cyclic daily injections	0.1 mg/kg	Water RAM, OR	No impact
				0.2 mg/kg	Water RAM, OR	Enhanced
	Simpkins et al., 1997a,b	Adultb	Continuousc	Pellet	2-way AA, MM	Enhanced
	Bimonte and Denenberg, 1999	2	Continuousc	10 mm capsule (0.025 in ID)	Water RAM	No impact
				2 × 10mm capsules (0.025 in ID)	Water RAM	Enhanced
	Gibbs, 1999	5	Continuousc	3 mm capsule (0.058 in ID)	DMP + scopolamine challenge	Enhanced
	Daniel et al., 1997	2	Continuousc	5 mm capsule (0.058 in ID)	RAM	Enhanced
	Talboom et al., 2008	4	Continuous	0.25 mg; pellet	MM	Enhanced
		16	Continuous	0.25 mg; pellet	MM	Enhanced
		24	Continuousc	0.25 mg; pellet	MM	Minor enhancement
	Daniel et al., 2006	12	Continuousc	5 mm capsule (0.058 in ID) at time of Ovx	RAM	Enhanced
				5 mm capsule (0.058 in ID)	RAM	No impact
				5 months post-Ovx
CEE	Barha and Galea, 2013	Adultb	Cyclic daily injections	10μg/0.10ml	RAM	Impaired
				20 μg/0.10ml	RAM	No impact
	Walf and Frye, 2008	13	Acute injection	0.625 mg/kg	OR	Enhanced
	Acosta et al., 2009a,b	13	Cyclic daily injectionsd	10 μg/day	MM, DMS	Enhanced
				20μg/day	MM, DMS	Enhanced
				30μg/day	MM, DMS	Enhanced
	Engler-Chiurazzi et al., 2011	13	Continuous	12 μg/day; pump	MM, DMS	Impaired
				24 μg/day; pump	Water RAM, DMS	Enhanced
				36 μg/day; pump	Water RAM, DMS	Enhanced
E1	Barha et al., 2009a,b	Adultb	Acute injection	0.30 μg/.10ml	Contextual Conditioned Fear Response	No impact
				1 μg/.10ml	Contextual Conditioned Fear Response	Impaired
				10 μg/0.1 ml	Contextual Conditioned Fear Response	No impact
	McClure et al., 2013	Adultb	Cyclic daily injections	10 μg/0.1 ml	MM	Impaired
	Engler-Chiurazzi et al., 2012	13	Continuous	2.6 μg/day; pump	DMS	No impact
				4.0 μg/day; pump	DMS	No impact
				8.0μg/day; pump	DMS	Impaired
17αE2	Luine et al., 2003	2	Acute injection	15 μg/kg	OR, OP	Enhanced
	Barha et al. 2009	Adultb	Acute injection	0.30 μg/.10ml	Contextual conditioned fear response	Enhanced
				1 μg/.10ml	Contextual conditioned fear response	Impaired
				10 μg/0.1 ml	Contextual conditioned fear response	Impaired

Note: All outcomes described are compared to Ovx animals given vehicle.

^aSee list of abbreviations for tests used.

^bWeights, but not ages, were provided.

^cSubcutaneous pellets or Silastic capsules were used. Doses listed, when provided in each reference, were based on approximate circulating estrogen levels after release. ID refers to inner diameter.

^dInjection regimen consisted of two days of treatment followed by two days off.